Botulinum toxin A was officially released in 1989 by the U.S. Food and Drug Administration for use in cosmetic treatment. In addition to the so-called frown lines between the eyebrows, botulinum toxin A is also used to treat forehead wrinkles and “laugh lines” around the eyes. It does this by blocking the transmission of signals …
Botox is given as a series of 31 to 39 tiny (0.1 ml) injections under the skin or into the muscles in and around the head of the forehead, above the ears, and into the neck and shoulders. The injections are repeated every 12 weeks until the patient no longer has chronic migraine, or until it is clear that treatment is not working. Normally a response is seen after the first or second set of injections; only about one in ten people respond to a third set of injections if the first two sets fail.